HistoBioTec presents:  histonova premium antibodies from dianova

Anti-Murine CD31 Antibody Clone SZ31 for standard FFPE tissues

Antibody clone SZ31 is the first antibody, which reacts specifically with murine CD31 in standard formalin-fixed paraffin-embedded tissue sections.
CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, platelets and certain T-cell subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells. CD31 is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion. CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence.
Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The rat clone SZ31 eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.

Product details:   Clone SZ31 as "goldstandard" for the analysis of angiogenesis in mouse models
(link to data sheet of DIA 310)